Okay, this got me curious. From the wikipedia article on viruses:
Viruses are considered by some biologists to be a life form, because they carry genetic material, reproduce, and evolve through natural selection, although they lack the key characteristics, such as cell structure, that are generally considered necessary criteria for defining life. Because they possess some but not all such qualities, viruses have been described as "organisms at the edge of life" and as replicators.
Theoretical biologist here. I consider viruses to define the lower edge of what I’d consider “alive.” I similarly consider prions to be “not alive,” but to define a position towards the upper limit of complex, self-reproducing chemistry. There’s some research going on here to better understand how replication reactions (maybe encased in a lipid bubble to keep the reaction free from the environment) may lead to increasing complexity and proto-cells. That’s not what prions are, but the idea is that a property like replication is necessary but not sufficient and to build from what we know regarding the environment and possible chemicals.
I consider a virus to be alive because they rise to the level of complexity and adaptive dynamics I feel should be associated with living systems. I’ll paint with a broad brush here, but they have genes, a division between genotype and phenotype, the populations evolve as part of an ecosystem with all of the associated dynamics of adaptation and speciation, and they have relatively complex structures consisting of multiple distinct elements. “Alive,” to me, shouldn’t be approached as a binary concept - I’m not sure what it conceptually adds to the discussion. Instead, I think it should be approached as a gradient of properties any one of which may be more or less present. I feel the same about intelligence, theory of mind, and animal communication.
The thing to remember when thinking about questions like this is that when science (or history or literature…) is taught as a beginner’s subject (primary and secondary school), it’s often approached in a highly simplified manner - simplified to the point of inaccuracy sometimes. Many instructors will take the approach of having students memorize lists for regurgitation on exams - the seven properties of life, a gene is a length of dna that encodes for a protein, the definition of a species, and so on. I don’t really like that approach, and to be honest I was never any good at it myself.
Thanks for posting this! While my knowledge of biology is quite limited, it's always great to get an informed person's take on an interesting topic.
Interesting, thanks! I'm someone that has been educated on viruses to a Radiolab level, and as such I'd like to hear your take on the idea that viruses used to be more complex organisms, which then evolved to be the simple and efficient form they are now.
Wildlife biologist here, and I have to concur with just about all of this.
I think we generally look at a viruses and consider them alive but just barely. While prions are not because they (proteins) are what is considered one of the building blocks for life. Self replication being one of the major criteria we'd look for. We look at a very macro level of life but our education and work has a strong overlap down here a well.
This is such a well written post! Gets the point id like to make across in a much better way than I could
They're not compromised of cells, can't self regulate, and can't replicate on their own and other organisms have to do that for them. The last point being important to our criteria for living. I was never taught as a biologist by anyone that they were alive
o7
"Obligate intracellular parasite" was drilled and showed up on multiple exams, along with all that you mentioned. I've also heard "escaped cellular machinery."
Absolutely fascinating...if a tad frightening.
Are these requirements for your definition of life? Is it possible for us to reproduce without relying on other organisms?
There you go defining humans as not alive again
I’m no scientist but I’d say, “Do it reproduce? Do it evolve? Do it try to survive? Bruh, it’s alive.”
I’m no scientist though. Just an idiot watching thangs. :p
It can't reproduce on its own, though. It needs a living cell to do that.
It seems to fail the last criteria there. They don't actively escape or react to predation. For the most part they aren't actively "trying" anything other than to just float around and replicate.
ok i'm not a biologist but having a cell structure as a prerequisite for defining life sounds very arbitrary to me.
I’ve been to this site hundreds of times, but this is the first time I’ve noticed
xkcd.com is best viewed with Netscape Navigator 4.0 or below on a Pentium 3±1 emulated in Javascript on an Apple IIGS at a screen resolution of 1024x1. Please enable your ad blockers, disable high-heat drying, and remove your device from Airplane Mode and set it to Boat Mode. For security reasons, please leave caps lock on while browsing.
The rare xkcd I find charming and relatable rather than charming and arcane.
They may not be alive but prions scare the ever living fuck out of me.
Of course
🚨 Viral meme detected
Is this what some virus really looks like? It looks like Tron-era CGI.
The image is in fact CGI, but yes there are several viruses known as bacteriophages that look like this.
Trying to find this confirmed electromagnetic scan of this phage led me down a truly fascinating rabbit hole about antibacterial phage therapy, taxonomy, and more. Let your curiosity take the better of you on Wikipedia
Such awesome pictures
Let's all take a moment to appreciate the 3D artist that was given the task to make this image, probably looked up a bunch of grainy references and then delivered this kick ass render.
At this scale we'd be seeing with electrons not photons, and everything would be gold coated. It's unlikely the head would be transparent. But other than that, not bad. False color gets applied to the B&W EM images, which helps.
Rabies is shaped like a bullet!
Artist's view of bacteriophages, viruses that infect bacteria and look like this. They attach to the bacterial wall with these fibers that look like spider legs, and then inject their DNA into the bacteria by contracting the sheath that attaches to the DNA-containing head. They kinda work like a syringe.
Yes, this is a bacteriophage. Truly fascinating stuff I'm lucky to work with every day.
More or less yes, that's the type of virus we learned about in biology class at least. Although there are various shapes a virus can have. Like covid that is round or other viruses that look more like bacteria.
Yes, I've always thought of bacteriophages as giant death robots of the virus world
Maybe undead ? That would explain all those viral zombie apocalypses.
These fuckers make me think they're some kind of robot. They look man-made AF.
Aliens.
Evidence of a false dichotomy to me
The third thing would be "inanimate"
Do prions count as another secret fourth thing?
Nah they're a single molecule. While they do have a mechanism to "reproduce", they cannot react to stimuli of any kind, or evolve. Of the 7 commonly accepted traits of life, viruses have 5-6 depending on where you stand with them not being able to reproduce on their own. (In comparison, while a tapeworm or other parasite might need a host, they bring their reproductive equipment with them).
Prions have 1 of those traits. They can't regulate an internal environment as they cannot have one, they lack any kind of organizational trait, they have no metabolism (the other one viruses lack), they do not grow, they don't adapt to their environment, and they do not respond to stimuli.
A digital thermometer has organization and responds to stimuli, so it's more alive than a prion.
Actually they can evolve, though I assume the range of evolution would be much narrower than traditional life forms, even viruses.
I'm basically a needle for injecting drugs into you without consent, fight me (I'll win anyway, some percentage of time).
I found this to be interesting. The word (and concept) of a virus predates its actual discovery by over 500 years.
The English word "virus" comes from the Latin vīrus, which refers to poison and other noxious liquids. Vīrus comes from the same Indo-European root as Sanskrit viṣa, Avestan vīša, and Ancient Greek ἰός (iós), which all mean "poison". The first attested use of "virus" in English appeared in 1398 in John Trevisa's translation of Bartholomeus Anglicus's De Proprietatibus Rerum. Virulent, from Latin virulentus ('poisonous'), dates to c. 1400. A meaning of 'agent that causes infectious disease' is first recorded in 1728, long before the discovery of viruses by Dmitri Ivanovsky in 1892.
I knew iOS was poison
It passed through the bacteria filters! So small that it passes by the filters and it kills--poison, toxin. But wait, it can be diluted to lowest effective concentration, and then with addition of host it grows back to high concentration. What poison does that?
I can’t find anything on the 1728 claim, but I remember hearing that Louis Pasteur coined the term while studying rabies in the 1880s!
The replicators are real. I still think the version from Stargate SG-1 are the scariest though.
Isn't metabolism one definition of life? If so, they're not alive.
They actually don't have a metabolism, that's why they don't fall into the definition of life in the first place.
Source Wikipedia: "Although they have genes, they do not have a cellular structure, which is often seen as the basic unit of life. Viruses do not have their own metabolism and require a host cell to make new products. They therefore cannot naturally reproduce outside a host cell"
You commented twice
They're checking the 'can reproduce' box for whether their comment alive or not.
Weird, i didn't even got a server timeout, which is usualy the cause.
Ok protein spooder
Viruses are Schroedinger's cat confirmed
Oh great virus! What is your wisdom?
R E P R O D U C E
Nice, thanks
While technically phages are viruses, i think it is important to label them as phages.
Typically a virus does not look like a robot. The by now rather well known SARS-CoV-2, with its spherical shape is a more common depiction of a virus: https://en.m.wikipedia.org/wiki/Virus
Bacteriophage look like little robots and from the view of a bacterium - they probably are the equivalent of a terminator: https://en.m.wikipedia.org/wiki/Bacteriophage
But phages are the most ubiquitous form overall. Maybe not as relevant if you mean viruses that infect humans.
Weaponized information.
Schrodinger's biology?
I'm just a quirky little lad.
