Could Psilocybin Be the Secret To Living Longer? Scientists Think So.
Could Psilocybin Be the Secret To Living Longer? Scientists Think So.
www.vice.com
Could Psilocybin Be the Secret To Living Longer? Scientists Think So.
44 comments
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Oh look, it's vice.com, so presumably these 'scientists' are from the University of Joe Rogan or U of Y(outube) or something.
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They do link to the actual study, which does not throw up any immediately obvious signs to be cautious for me, but I also couldn't do the detailed work of deeper research myself. They reference a hypothesis that preceded the study, which they were trying to test with this. I don't know if this is a case of bias or even manipulation at work, but at least at a superficial glance, it doesn't immediately scream "total hacks doing unscientific things."
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I just checked the study and it's interesting but limited - they only tested this on female mice (not males), with a small sample size (10 mice per group), and the mice were tripping balls during the experiment based on their "head-twitch response" measurments lol.
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Cant wait for this to be exploited by the rich and still be illegal for the poor
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still need someone to explain me why a chemical that can make people happy has to be illegal.
if there are also very dangerous, I get it. but if the risk is taking a long nap and changing your mind. then why would the government care?
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The (US) government has a long history of outlawing useful, helpful or otherwise enjoyable things (MDMA, weed and psilocybin) while allowing more destructive things to proliferate (alcohol, opiates). Many governments worldwide still outlaw marijuana and some places will straight up execute people for it (singapore). Keeps the population in check and helped fuel conflict within the lower class to keep them from looking upward.
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It’s not difficult to say, allow nature to do its thing and allow cubensis to grow naturally, in a shoebox.
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Who the fuck wants to live longer?
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Slowing cell aging could mean better health for longer, even if you don't die (much) later.
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living longer is often correlated with staying healthy for longer, and that's a nice thing i guess
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Me. I want to see us get serious about fighting global warming, so I know I’m leaving my kids a better world
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Good news, they find a treatment regimen that when applied to mice cause them to have a health span several times longer than the average health span of a mouse.
Bad news, the treatment regimen when applied to humans causes them to have a health span several times longer than the average health span of a mouse.
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Twist: It was all relative to the life span of a lab mouse, whos life is a living hell in nine out of ten cases.
Meaning... the results will only confirm that there are controlling substances that will allow a populace to endure literal torture, and enable the rich to literally take over the world NOT for efficacy but for sheer chemical complacency.
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I've partied with scientists so I'm not surprised
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Scientists are just cool like that
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Please be a "yes," please be a "yes..."
Edit: WOO! It's a "looks that way in cell cultures so far!"🥳
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I haven't gone looking forthe souce paper, but from the article it looks like seretonin was the actual compound that's having a beneficial effect, specifically serotonin outside the brain.
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So how is a psychedelic pulling this off? The secret could be serotonin receptors found throughout the body, not just in the brain. When activated, they seem to trigger a cascade of effects that reduce stress, preserve DNA, and promote long-term cell health.
They're talking about psilocin's activity at serotonin receptors, I'm pretty sure
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If you do happen to find it, please post a link. I'll go looking also.
Never mind. It was linked in the article.The paper in question.
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Oooh, yeah... reread it more carefully... wellp! At least we do get some of that from 'shrooms!:))) Partial win!:)))
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Well, I’m definitely going to stop then.
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should really source the science paper, it came from then a site like vice.
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Be the change you want to see…
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To evaluate the impact of psilocybin on longevity in vivo, aged (19 month) female mice were treated with vehicle [vehicle is what the psilocybin was suspended in for injection] or psilocybin [actually vehicle + psilocybin] once/month for 10 months; mice were initially given a low-dose (5 mg/kg) for the first treatment followed monthly high-dose (15 mg/kg) treatment for a total of 10 treatments. We elected to utilize 19-month old mice, which is roughly equivalent to 60–65 human years, in order to evaluate its therapeutic potential as a clinically-relevant anti-aging intervention.
Within 30 min post-treatment, mice exhibited increased head-twitch response, which is a well-established behavioral indicator of hallucinogenic impacts of psilocybin in mice. Both psilocybin and vehicle groups exhibited some loss in body weight from the start to end of the treatment protocol, however weight loss was not significantly different in vehicle vs. psilocybin-treated mice. Notably, psilocybin treated mice demonstrated significantly higher survival (80%), compared to vehicle (50%).
Although not quantitatively measured, psilocybin-treated mice exhibited phenotypic improvements in overall fur quality, including hair growth and reductions in white hair compared to vehicle-treated mice.
In summary, we provide the first experimental evidence demonstrating that psilocybin treatment can enhance survival in aged mice.
So, caveats:
- This is the first study; while further studies may show a similar result, we won't know for sure until they are completed. This could be a fluke. This was neither a double blind nor a placebo study; it is possible things like researcher impacts could influence the outcomes.
- This was neither a double blind nor a placebo study; it is possible things like researcher impacts could influence the outcomes.
- Typical doses for psilocybin are 0.2–0.4 mg/kg in therapeutic settings, 4mg/kg for microdosing, to up to 20 mg/kg to be legitimately tripping; like the mice, if you use this regimen you will need to set aside a day to be tripping once a month, and after 10 months take a heroic dose and have a really big trip. Not impossible to arrange for many people, but this is not a regimen you can do while completely going about your regular day-to-day.
TLDR: Promising results in an under studies area. More studies are required to confirm results. Following this regimen will cause a non-trivial disruption in your monthly routine.
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Turns out Melange was on Earth this whole time.
44 comments
Oh thank god. I thought it was diet and exercise so this comes as a huge relief.
technically still diet
If you ever talk to anyone over the age of 100 every single one of them without fail, swears that the secrets to long life is brandy and cigarettes.
Either they're really on to something or they're trying to kill everyone else off.
I looked into genetic factors of centurions out of curiousity before and it does largely seem to be nature rather than nurture. Centurions tend to have siblings that are also centurions, both of whom typically have overactive telomerase enzymes. Apparently some type of enzyme that prevents aging of cells. Theoretically, if those same people avoided alcohol and cigs their whole life, they would have lived even longer.