Revolution in pain management: first non-opioid drug arrives
Revolution in pain management: first non-opioid drug arrives
JOURNAVX bottle and tablet (Photo: Business Wire) The Food and Drug Administration has approved suzetrigine for the treatment of moderate to severe acute pain, a new selective… by davideownzall
There's a lot of snark, but the idea is this only inhibits pain in the peripheries, so it isn't so psychoactively impacting. You don't get sedated, the addiction profile is way less, and the LD50 means OD'ing is much harder. I'm sure there's dependency potential, but it seems this is NOT recreational, which is huge, and if the sedation is less and you can take this and still function, it could be a game changer, allowing people impacted by chronic pain to re-enter the work force and have a better quality of life:
https://en.wikipedia.org/wiki/Suzetrigine https://pubmed.ncbi.nlm.nih.gov/39775738/
For a moment I thought there was a drug called Recreationol. It sounded like a hell of a party.
allowing people impacted by chronic pain to re-enter the work force
You mean they're just going to force utterly crippled and suffering people to work instead of taking some time to heal in a hospital...
No, lots of people out there years out from an accident or injury can't work and it leads to the opioid addiction cycle; having an option to control the pain and get people able to either work or do hobbies again, or do things with their families, would be huge.
Nowhere in their comment did they even come close to implying what you’re suggesting. There are many folk who’d love to go back to doing the things they love, which includes actual work, but can’t, because the hospital did all they could and sent them on their way to deal with crippling pain on their own. This might let those people go back to doing what they love to do.
Stop making shit up.
Not everywhere is the US.
Hopefully it's not addictive, so maybe - just fucking maybe - people actually in pain can get it without jumping through a million hoops and being treated like drug-addicted criminals.
That'd be... neat.
I will bite. How much? Unless its cheaper than opiates, No one is going to put their profit margin above the common good of society.
“Vertex says that the medication will be available for $15.50 per 50-milligram pill, or about $30 per day. In contrast, comparable doses of the hydrocodone and acetaminophen combination retail for an average of about $7 per day.”
I think you (unintentionally) have that backwards. The companies absolutely will and do put their profit margin above the common good.
Yeah…. My bad
What a weird site.
PR releases b/w standard blog fare and meta numbers discussion?
significantly more favorable side effect profile
So is this 3 days until an addiction starts vs the usual 2 days? Where’s the deets?
It does but they didnt explain. It's the reduced impact on a person's brain that makes it less addictive by only blocking pain receptors at periphery locations and not in the brain. Removing the feeling of being high that opiates provide and just numbs the pain.
Journavx, which has been clinically proven to be as effective as opioids in the treatment of acute post-operative pain but with a significantly more favorable side effect profile. The drug blocks pain signals that are only found in the periphery, not in the brain, without the limitations of currently available therapies.
There’s this at the bottom of the article. It may have what you’re looking for.
Aspirin has entered chat.
Even if it had similar addiction profiles to opioids I'd be all for it. Opioid allergies are very common and those of us who have them also deserve to not be in agony after surgeries or physical trauma.
In fact, I worry that if its nonaddictive it may be pushed onto people who are allergic or nonresponsive to it similar to how nonstimulant adhd meds are. That doesn't mean I'm not all for nonaddictive painkillers, I'm 100% in favor and if we had a few options that can cover our bases I'd be in favor of shelving the poppy juice into a last resort role, but I hope people don't lose their sense of nuance in it.
This does sound like great news.
shrugs in stoner
Its great! And if you pop the miniature eyes that grow behind your ear in the first month, you don't have to get them surgically removed! A lot of people might think "hmm extra eyes! Heck yeah!" But what they don't get is how weird everything looks from behind. And the blinking! Nobody wants to be behind you and watch you blink. But you just pop them first sight and you'll be happy as a clown!... Clam! Sorry!
Is this BBB soluble like gabapentin?
so what, are normal pain relief pills opioids? or do they just not count as pain relief somehow?