A war orphan from Sierra Leone, DePrince moved to the US and ended up performing with Beyoncé.
Ballerina Michaela Mabinty DePrince, who performed with Beyoncé and was seen by many as a trailblazer, has died at the age of 29.
A spokesperson announced her death on her personal Instagram page and in a statement her family said she was an "unforgettable inspiration to everyone who knew her or heard her story".
The cause of death has not been given.
DePrince made a remarkable journey from suffering as an orphan in war-torn Sierra Leone to numerous accolades in the world of international dance.
Her family said her death had been "sudden", adding: "Michaela touched so many lives across the world, including ours."
Tributes have been pouring in, including from others in the ballet community.
I just watched a video where she was talking about being stabbed in the belly with a machete by a child soldier right after her pregnant teacher was cut open in front of her by soldiers who wanted to know if the teacher’s baby was a girl or a boy.
I think if she'd been in a car accident or something similar, they'd be forthcoming about it. I think this suggests a terrible illness. Sad news. Didn't know who she was, but it's a shame that someone who was truly gifted didn't get to continue achieving greatness.