D&D 5E (I want to say Level Up: Advanced 5th Edition because it solves the problems I have with D&D 5E but I haven't had the chance to play it yet because I first need to finish my current campaigns)
(Please no PbtA or Burning Wheel stuff. I've tried it but it's very much not my thing.)
I don't use ChatGPT and don't plan to. For me, part of the fun of running games is being creative and doing the work of coming up with stuff myself. I don't have as much of an issue with ChatGPT as with machine generated images, so that's not why I avoid it. I just think the creative work is part of the experience, and us humans can also do that far better than a computer program. ChatGPT can't easily draw on campaign-specific themes and symbolism, can't foreshadow the greater mysteries going on. I mean, it likely can if specifically prompted to, but then you're still doing most of the work myself.
And if I want to randomly generate something... Well, we're all into TTRPG's; that's what dice are for. (Or tarot decks. I have too many of those. They're just so pretty and I keep hoarding them.)
In case you want to play D&D 5E but without supporting WotC while also having more customisation options: Check out Level Up: Advanced 5th Edition. It's also got its own thing for inspiration: during character creation, you pick – other than heritage, background, and culture – a destiny. It's what your character is meant to do, their story, their goals. This destiny gives you another means of gaining inspiration (things tied to your destiny) and a unique way to spend inspiration. (Also, you gain a special destiny feat when you accomplish a big thing related to your destiny!)
You can use Ripper's script here to check your modules.