If you always wondered or wanted to play a more brutal game of American football and had fantasy elements, I've heard good things about Blood Bowl 2. It's Warhammer smashed into American football.
In the retro space, the Genesis/Mega Drive had "Mutant League Football" which involved various teams of monsters (Skeletons, Orc-like "Mutants," etc.) playing on a field strewn with land mines and bottomless pits, and as the coach you had options like "Bribe ref" which would need to be immediately countered with "kill ref."
How interesting. I had never heard of that game before, and never thought that there was an earlier game like Blood Bowl, but from... checks notes 1993. (!?!)
[Nintendo lawyers activate]