What's your biggest debuff?

ME/CFS.

It imposes a strict stamina limit. If you go over the stamina limit your energy levels will be reduced, you'll get dizzy, feel ill, get headaches, etc. If you go over too much or too often, your stamina is permanently reduced and you start taking physical damage. You won't know if you've gone over the limit until a couple of days later.

Shitty design. Totally ruins gameplay.

Man, same. It's also caused central dysautonomia, so I've got random problems like POTS, hyperhidrosis, digestive problems, and on and on.
- It's the worst. Let's hope they patch it.

Inattentive adhd. My mind likes to go on little vacations.

Having to make a concentration savings throw for every action is ridiculous.
Rolling with disadvantage if it is something I don't want to do is even worse.

Well, currently I've got covid, so.... That

Ya I think that counts
Twinsies. 104F fever. I want to die.

IPAH

Permanent debuff to stamina.
Permanent Fatigued status.
Difficult terrain is now Greater difficult terrain.

Requires daily potion, if potion is missed or unable to be obtained, stamina is set to 0 and cannot rise until the next potion is taken. You are also Sickened 1 and cannot be rid of this until the next potion is taken.

Spells with a verbal component now require a DC 5 flat check. On a failure, the spell fails and you are Suffocating. The check increases to a DC 11 while in Difficult Terrain.

Permanent Fatigued status
Sound like me. Except I don't have enough stamina to go to the wizard to get some potions to negate these debuffs (antidepressants)

OCD, ADD and mild face blindness

PS: Oh and sleep apnea, I hate it

PPS: forgot about vitiligo... Damn I really lost at the genetic lottery

I'm gonna stop there before I add depression

AuDHD is keeping me from learning new skills, forming routines, and overall following my dreams in favor of doing stuff that grants immediate dopamine.

autism
adhd
add
auditory processing disorder (minor, only slighty annoying)
depression
anxiety
self harm
labido so low im essentially asexual (?)
gender dysphoria (I'm also possibly intersex apparently??)

Proneness to migraines.

Too much stress or noise can set off a constant -1 to -5 hit to stamina/health for up to 10 hours. Perception is up but Intelligence takes a dive. Also takes extra food to regain what was lost, but selection is limited due to nausea. Can be counteracted with coffee and acetaminophen if hit early enough, else it goes to Migraine+.

Migraine+ includes extra weakness to light and insomnia, meaning spell slots can’t be reset until the debuff wears off. Migraine+ can last up to two weeks.

Same here. Trigger by perfume too. And effort. Intensive effort, migraine +.
But the most difficult is the permanent brain fog. I became dumber and slower since I have chronic migraines.
So yeah, migraines are my best debuff, event if I have others.

Laziness. Every day roll a d20. If I roll less than 5 suffer -5 initiative, -5% experience gain, -5 will save until next long rest.

Diagnosed with GERD

Constant burping throughout day

I can't sleep properly at night without burping for 30 minutes

Prone to heartburns

Forced to have a healthy diet

Cuz of said burping, teeth and gums are exposed to more acid, so I'm also forced to have good dental hygiene

Constantly feel bloated with air

Generally just a constant feeling of unwell, and whenever you do something or smell something that might cause you to gag or feel like puking, i feel it ten times harder (based on experience)

Running on 30 minutes of sleep, and my work day is about to start. Luckily I work from home, and once I've cleared my morning inbox I think I will crawl into bed.

Running on 30 minutes of sleep
Self inflicted or nah
- Combination of a 5 year old wanting to sleep next to her parents, and a heatwave. I chose to stay on the couch in an attempt to let my GF at least get some sleep before work. It's a comfortable couch, but not for sleeping.