Not even nukes can kill them

Fully upgraded uranium tank rounds kill them pretty fast. Just make sure to stay away from explosive ammo

You're not using enough nuke.

But they can? One nuke to the head works for small. Two works for medium. I haven't come across a large yet.

Am I the only one who's not had a problem with just using basic turrets to wipe them out in 5 seconds? Made entirely from free resources on Vulc, the only cost is bot attrition from the dust cloud.

You can one-shot a medium worm with an epic quality railgun round. Large worms require about ten epic railgun rounds

I set up 10 - 20 artillery cannons, 5 shells each, and spammed it until it went down.

Likely a bit over kill, worked for small and medium, haven't don't large yet