Is it possible to host a website using a VPN and port forwarding?

I'm able to use my VPN to distribute files via Soulseek/Nicotine+. Can I do this with its IP and port forwarding so people can connect to a website hosted on my machine from the internet?

I'm imagining they'd be able to connect with the basic IP:port address, but I'm really not even sure if it's possible.

I'm looking into using NGINX for this. If something else is more appropriate, I'd love to know.