Common sugar substitute shown to impair brain cells, boost stroke risk

I found this article that mentions how normal consumption levels are far lower than 6mM. https://www.fda.gov/media/182122/download

Yes exactly. This is an interesting finding that warrants more research, but high concentration in a Petri dish does not reflect what happens in the body.
- I have a rule of thumb. If experts and doctors recommend pregnant woman to not eat or drink anything, it's probably better to stay away from it.

Is there a way to view the full paper? I'm curious if they properly isolated for people who are also overweight (the kind of people who would consume this artificial sweetener).

https://doi.org/10.1152/japplphysiol.00276.2025

Why cannot they just put erythriol in the title?

Then you wouldn’t click the link to find out what it was.
- Yeah but shit like this makes me not want to read the article at all. I just skim it until I find what the thing is.
  Just like some annoying marketing campaigns with ads that you have no fucking idea what they are about (like ".it's coming", "soon" and shit like that) and only find out like a month later when they make a new campaign actually telling you that. I will never engage with that company or buy the product just because I hate ads like that.
Then you wouldn’t need to click the link and read 20,000 words and 15 adverts before the buried headline is finally revealed.
ProZD - clickbait/YOU WON'T BELIEVE meme

Our study adds to the evidence suggesting that non-nutritive sweeteners that have generally been purported to be safe, may not come without negative health consequences,”

No. It adds to research about this sweetener. You can't generalize beyond that.

Except for the numerous other artificial sweeteners that have been found to also have negative effects. This has been a trend, and I think that's what they meant by that statement
- Their research says nothing about sweeteners that weren't part of their study.

What’s crazy is that I wasn’t familiar with erythritol, and searched to see what had it as an ingredient. The entire first page of results were almost all the same AI generated cream touting the benefits of erythritol, like they were trying to sell me on it. And no specific foods were listed that had it as an ingredient.

There were a lot of things like “consider the delicious possibilities that erythritol can bring to your table.” Someone is trying to sell it that hard, then that alone tells me I should probably avoid it.

That's the new normal for internet search results, not a concerted effort by big erythritol...

https://www.emjreviews.com/neurology/news/artificial-sweetener-erythritol-linked-to-brain-vascular-cell-dysfunction/

Source that actually names the thing in its title.

Unfortunately it's of course barely readable for laypeople. So is there a safe upper limit? Like if I put a teaspoon of it in my cup of coffee, am I destroying my brain?

Cells were treated with 6 mM erythritol, replicating the concentration found in a typical serving of an artificially sweetened drink, for three hours.

What's "mM"?

Millimolar https://en.wikipedia.org/wiki/Molar_concentration?wprov=sfla1
- Yep. Erythiol has a molecular weight of 122 g/mol, so 6 mM is the same as 0.732 g/liter.
  It should be noted that the cells were exposed to the full concentration in the drinks, so the concentration they encountered is much higher than it is when it has been diluted by all the water in our bodies after we drink it.
- Ah. I remember that from desperately trying to wrap my head around it in Chemistry class. Thank you, it's impossible to search for.

I mean, this was brain cells directly exposed to it in concentrations far higher than would occur in a human body after metabolism with no secondary carbohydrates that would likely come with eating said food (units you like eating spoonfuls of pure Splenda I suppose).