This update broke a game for me, namely "Castle of the Winds", it's a 16-bit windows 3.1 game. Not really a huge loss as I can just run it in win3.1 I have in dosbox - but it was pretty nice to have in modern resolution :D
IIRC I have tried the game with proton(and/or -ge), it never worked on those.
I'm probably just going to accept dosbox for the game (it also fixes some minor graphics issues with it). I'm mostly concerned about old game installers - but then again, gog/steam don't have those installers anyway, so it's only an issue if the user is adamant on using original install media or so.