To be honest, when I read the title I wondered if fire is what they were referring to. After all, heat is basically just particles bumping around... could be described as vibrating.
This paper refers to neither a common drug, nor vitamin. And if you’d read the paper, which is still in ‘prepublication’, you may have noticed that it refers to a novel process. Patients are generally, in my clinical experience averse to being placed in fires AND to being shot, even therapeutically. So I have to ask, is your purpose to promote XKCD? A Nobel pursuit, as far as I can tell. Or to sow discord in a scientific discussion? Which is annoying at best.
Aminocyanine molecules are already used in bioimaging as synthetic dyes. Commonly used in low doses to detect cancer, they stay stable in water and are very good at attaching themselves to the outside of cells.
Looks like an interesting choice, since they were already made to attach to cancer cells.
They work like an existing method, but with infrared light vs visible, which penetrates deeper into the body.
The thing about the used molecules is that they attach to the cancer more than other cells.
Apart from that you can concentrate the infrared light at the main clusters.
I'd say it is an improvement. Even if only the main clusters are destroyed it's noninvasive way to reduce the chance of mutation (less cancer cells means less chances for a mutation to gain chemo resistance).
Yeah I’ve read the article and I’ve gone and had a little look at the scientific paper as well. The paper only mentions the effect of the molecule on cancer cells and does not mention what effect it has or may have on normal tissue. Interestingly for their mice model they delivered the drug intratumourally. To me this suggests that the drug is not selectively taken up by the tumour cells and they you need to get around this by limiting the delivery of the drug to the site of the cancer. This is just my speculation though. However, if true it would have implications on the practicality of using this method as a cancer therapy.
Well, killing 99% of cancer cells is quite useless, the 1% left will now thrive and if they survived because they were different (and not just luckily escaping the treatment) you now have 100% of cancer cells you can't treat anymore.
Better case, the 1% "lucky" cancer cells just re-invade.
Best case scenario is that your immune system takes care of the final 1%. Worse case scenario is exactly as you described and you get mets that are resistant to therapy.
I thought the issue is your immune system wouldn’t know to take care of the final 1%. As that’s the issue with cancer: it isn’t an antigen. It is something made by the body so it’s already coated in a natural sheep’s clothing to escape being detected by the immune system. Hence why breakthroughs in marking the cells is so important so at least an outside force can treat it.