I mean, correct me if I’m wrong, but aren’t Nature and its subject-specific varieties considered some of the most reputable and prestigious scientific publications?
Yeah, getting published in Nature is a career gold star achievement. They’re very high impact (meaning many other scientific papers cite their articles).
Anecdotal only, sorry. I'm sure it varies by field, and it's more about letters than longer papers. There are probably fields where Nature is excellent, but I know that there is at least one where the odds of a letter to Nature being accurate a few years later is about 50%.
I'm a researcher. Nature is good but it still has mistakes. Sometimes they are a tad sloppy but they are still far, far better than what you may know from popular science. In general, some mistakes are normal and expected because science works by finding and fixing mistakes, not by immediately discovering ultimate truth. This applies even in math.
If we go by impact factor (a measure of how often the articles a journal publishes are cited elsewhere), various Nature publications are six of the top ten journals in the world and Nature itself is 15th