I am autistic, which you probably could have just derived from the rest of this comment. Questions like these are so terrifying to me. So I always have a fun fact on hand.
"What's new?"
"I just learned that only female cats have a calico pattern!"
Then you can talk about cats instead of your life.
You're right, that does sound particularly like something an autistic person would say. It's also something I'd be perfectly happy to hear and engage with.
It's not an absolute rule, but it's true in the vast majority of cases. The coloring is on the X chromosome, and males usually have only one, but some males with have an extra X chromosome (XXY) and those can be calico. It's rare.