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Researchers have discovered how to diagnose a severe form of depression known as ‘melancholia’ by analysing facial expressions and brain activity.

www.nature.com Markers of positive affect and brain state synchrony discriminate melancholic from non-melancholic depression using naturalistic stimuli - Molecular Psychiatry

Melancholia has been proposed as a qualitatively distinct depressive subtype associated with a characteristic symptom profile (psychomotor retardation, profound anhedonia) and a better response to biological therapies. Existing work has suggested that individuals with melancholia are blunted in thei...

Markers of positive affect and brain state synchrony discriminate melancholic from non-melancholic depression using naturalistic stimuli - Molecular Psychiatry
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