Medicine
- Researchers have discovered how to diagnose a severe form of depression known as āmelancholiaā by analysing facial expressions and brain activity.www.nature.com Markers of positive affect and brain state synchrony discriminate melancholic from non-melancholic depression using naturalistic stimuli - Molecular Psychiatry
Melancholia has been proposed as a qualitatively distinct depressive subtype associated with a characteristic symptom profile (psychomotor retardation, profound anhedonia) and a better response to biological therapies. Existing work has suggested that individuals with melancholia are blunted in thei...
- phys.org Researchers discover localized pain relief using known chemical reaction
A team of international researchers including those from the University of Adelaide have taken a well-known chemical reaction as the basis of a new generation of targeted pain relief medication.
- www.404media.co Leaked Training Shows How Doctors in New Yorkās Biggest Hospital System Are Using AI
At Northwell Health, executives are encouraging clinicians and all 85,000 employees to use a tool called AI Hub, according to a presentation obtained by 404 Media.
My thoughts are summarized by this line
> Casey Fiesler, Associate Professor of Information Science at University of Colorado Boulder, told me in a call that while itās good for physicians to be discouraged from putting patient data into the open-web version of ChatGPT, how the Northwell network implements privacy safeguards is importantāas is education for users. āI would hope that if hospital staff is being encouraged to use these tools, that there is some significant education about how they work and how it's appropriate and not appropriate,ā she said. āI would be uncomfortable with medical providers using this technology without understanding the limitations and risks. ā
It's good to have an AI model running on the internal network, to help with emails and the such. A model such as Perplexity could be good for parsing research articles, as long as the user clicks the links to follow-up in the sources.
It's not good to use it for tasks that traditional "AI" was already doing, because traditional AI doesn't hallucinate and it doesn't require so much processing power.
It absolutely should not be used for diagnosis or insurance claims.
- UnitedHealth says Change Healthcare hack affects over 100 million, the largest-ever US healthcare data breachtechcrunch.com UnitedHealth says Change Healthcare hack affects over 100 million, the largest-ever US healthcare data breach | TechCrunch
UnitedHealth, the largest U.S. health insurance provider, blamed a Russia-based ransomware gang for the huge data breach of U.S. medical data.
cross-posted from: https://lemmy.zip/post/25095680
> > UnitedHealth, the largest U.S. health insurance provider, blamed a Russia-based ransomware gang for the huge data breach of U.S. medical data.
- theconversation.com Who cares? How virtual health is changing in-home caregiving
Three-quarters of health care in Canada is provided at home by unpaid family caregivers. Not only is this essential health-care work often unrecognized and under-supported, it is rapidly changing.
cross-posted from: https://lemmy.ca/post/31063000
> Intro section below: > > > Seventy-five per cent of health care in Canada is provided at home by unpaid family caregivers. Not only is this essential health-care work often unrecognized and under-supported, it is rapidly changing. > > > > Since the COVID-19 pandemic, many health-care appointments have shifted to telephone and videoconferencing. This change in the mode of health-care delivery has now become more fully integrated into the Canadian health-care system. > > > > While a lot of policy and research has focused on the impact of this transition on doctors and patients, these changes also have important implications for caregivers. > > > > With a growing portion of Canadians opting to age in place at home, family members will increasingly be relied upon to provide care. However, unlike professional health-care workers, family caregivers are generally not compensated for their labour. > A middle-aged man helping an older man take his medication > With a growing portion of Canadians opting to age in place at home, family members will increasingly be relied upon to provide care. (Shutterstock) > > > > In fact, the act of caregiving is associated with personal costs. Caregivers often must take time away from paid work to provide care, which in turn affects their financial security. Notably, women make up the major share of caregivers in Canada. > > > > To better understand the needs of caregivers, our research team reviewed existing studies, and conducted interviews and workshops with caregivers and others taking part in virtual health. Our findings shed light on how virtual care has so far interacted with existing inequities to create opportunities and challenges for caregivers.
- Six transplant patients in Brazil contract HIV from infected organs
cross-posted from: https://lemmy.zip/post/24371438
> > Six transplant patients tested positive for HIV after receiving infected organs from the Rio de Janeiro organ donation service, state officials said on Friday. > > Archived version: https://archive.ph/3F8Pi > > SpinScore: https://spinscore.io/?url=https%3A%2F%2Fwww.reuters.com%2Fworld%2Famericas%2Fsix-transplant-patients-brazil-contract-hiv-infected-organs-2024-10-11%2F
- Did y'all know we're running low on IV and Dialysis fluids because of the hurricane and this isn't even the first time this has happened?www.cnn.com US hospitals strained by IV fluid supply limits after Helene hit production site | CNN
Hospitals across the United States are rationing critical intravenous fluids and postponing some surgeries as the national supply chain continues to reel from severe disruptions triggered by Hurricane Helene two weeks ago. Now more threats ā including respiratory virus season and another hurricane ā...
Also happened in 2017 when the same supplier's facility in Puerto Rico got hit (the US's primary IV / dialysis fluid supplier). They already knew this was an issue and never actually fixed it. IV fluids are one of the most basic medical supplies. And if I'm hearing correctly a lot of hospitals aren't rescheduling elective surgeries (and some electives are necessary / time limited but many aren't or are even cosmetic). Completely preventable problem that could be being managed better even now it's happened.
- "Drug makers canāt make knockoff weight-loss drugs anymoreāand theyāre mad"arstechnica.com Drug makers canāt make knockoff weight-loss drugs anymoreāand theyāre mad
Compounding pharmacies could make knockoffs during shortage. But FDA says itās over.
cross-posted from: https://rss.ponder.cat/post/40024
- Nobel Prize in medicine goes to two American biologists for work on the discovery of microRNAwww.cnn.com Nobel Prize in medicine goes to two American biologists for work on the discovery of microRNA | CNN
The 2024 Nobel Prize in physiology or medicine has been awarded to US scientists Victor Ambros and Gary Ruvkun for their work on the discovery of microRNA, a molecule that governs how cells in the body function.
- Did a top NIH official manipulate Alzheimer's and Parkinsonās studies for decades? | science.org
Summary
> Eliezer Masliah, who since 2016 has been the head of the Division of Neuroscience in the National Institute on Aging (NIA), and whose scientific publication record over at least the past 25 years shows multiple, widespread, blatant instances of fraud.
More details
> Masliah appeared an ideal selection. The physician and neuropathologist conducted research at the University of California San Diego (UCSD) for decades, and his drive, curiosity, and productivity propelled him into the top ranks of scholars on Alzheimerās and Parkinsonās disease. His roughly 800 research papers, many on how those conditions damage synapses, the junctions between neurons, have made him one of the most cited scientists in his field. His work on topics including alpha-synucleināa protein linked to both diseasesācontinues to influence basic and clinical science.
> But over the past 2 years questions have arisen about some of Masliahās research. A Science investigation has now found that scores of his lab studies at UCSD and NIA are riddled with apparently falsified Western blotsāimages used to show the presence of proteinsāand micrographs of brain tissue. Numerous images seem to have been inappropriately reused within and across papers, sometimes published years apart in different journals, describing divergent experimental conditions. > > After Science brought initial concerns about Masliahās work to their attention, a neuroscientist and forensic analysts specializing in scientific work who had previously worked with Science produced a 300-page dossier revealing a steady stream of suspect images between 1997 and 2023 in 132 of his published research papers. (Science did not pay them for their work.) āIn our opinion, this pattern of anomalous data raises a credible concern for research misconduct and calls into question a remarkably large body of scientific work,ā they concluded.
Related blog post on some drugs/therapeutic targets that rely on this work: https://www.science.org/content/blog-post/fraud-so-much-fraud
- PSA for physicians in the US: "Your data is being sold by the AMA through their 'AMA Physician Professional Data' program"
Saw this post on another site, and thought it would be helpful to link here
> Go to the link to request that they add a Do Not Contact (DOC) or Do Not Release (DOC) restriction to their AMA Physician Professional Data record
> AMA Link.
> I have worked on the Carrier side of malpractice insurance for nearly 10 years. Working in their marketing departments I can tell you this type of data was routinely purchased for mailers. If we wanted to we could buy full rights to the data, which allowed us to upload it into our SalesForce and CRM systems. They even offered to sell us data on physician computer activity by specialty so we could line up our email pushes with their most receptive times. > > I have even heard of carriers purchasing patient billing data to help determine a physician's professional liability risk profile. So if you have what they would deem a "riskier" patient population, they could charge you more. The old way was based on a broad risk profile by specialty and procedure codes.
- www.nature.com How a trove of cancer genomes could improve kidsā leukaemia treatment
Analysis shows that a type of fast-growing paediatric cancer has 15 distinct subtypes, each linked to responsiveness to particular therapies.
cross-posted from: https://rss.ponder.cat/post/11189
- theconversation.com All for one, not one for all: The promise and challenges of personalized medicine
Personalized medicine is a promising treatment for recurrent cancer and superbugs, but it is labour-intensive and expensive, and pathways for its regulatory approval and reimbursement are complicated.
> For most of the medicines currently in use, a single drug is prescribed to many people. But sometimes, an individual patient needs a customized drug. Personalized medicine tailors treatments for a specific patient or a handful of patients. It holds great promise for treating certain life-threatening conditions. However, such treatments can be expensive, difficult to develop and labour-intensive. > > Today in The Conversation Canada, Lori Burrows and Elizabeth Li of McMaster University write about the promise and challenges of personalized medicine. Treatments like CAR T-cell therapy for relapsed cancers and phage therapy for antibiotic resistant superbugs can save lives, but the high costs that come with such individualized therapies are a major barrier. There are other hurdles, too, including drug approvals and regulations.
- www.theguardian.com Poor physical health associated with depression through link to brain, research shows
Study identifies biological pathways through which the weakness of organs may lead to poor brain health, and in turn mental health problems
- theconversation.com Paramedics treating patientsā palliative needs at home benefits everyone
Training paramedics to provide home-based palliative care lets severely ill patients remain at home and takes pressure off emergency departments and the health system.
- www.scientificamerican.com Combining Ayahuasca Compound with Drugs like Ozempic Could Help Treat Diabetes, Mouse Model Suggests
Researchers combined the drug harmine with a medication similar to Ozempic to boost the number and function of human insulin-producing cells transplanted into mice
- Vancouver doctor first in Canada to use new suturing deviceglobalnews.ca Vancouver doctor first in Canada to use new suturing device | Globalnews.ca
Dr. Roberto Trasolini said doctors can place the Overstitch device at the end of a scope and sutures can then be performed internally.
cross-posted from: https://rss.ponder.cat/post/1945
- www.sciencedaily.com Scientists identify possible new transmission factor in hospital-acquired Klebsiella infections
Scientists have identified a critical factor that may contribute to the spread of hospital-acquired infections (HAIs), shedding light on why these infections are so difficult to combat. Their study reveals that the dangerous multidrug resistant (MDR) pathogen, Klebsiella, thrives under nutrient-depr...
- Two people dead in listeria outbreak linked to recalled plant-based milk Ā· Globe and Mail | Kelly Grantwww.theglobeandmail.com Two people dead in listeria outbreak linked to recalled plant-based milk
The Canadian Food Inspection Agency has traced the outbreak to several alternative milks from Silk and Great Value
article archive link: https://web.archive.org/web/20240719142236/https://www.theglobeandmail.com/canada/article-two-people-dead-in-listeria-outbreak-linked-to-recalled-plant-based/
- Sources of specialist physician fee variation: Evidence from Australian health insurance claims data
Highlights
> - This study investigates why specialist physician fees vary. > - We consider variation between patients, physicians, specialties, and other factors. > - We find variation between physicians dominates other sources. > - Contrary to common beliefs, patient factors account for little of the variation. > - Our results inform policy to improve price transparency in specialist care market.
More context:
> Although Australia has a publicly funded health system that provides universal health coverage, about 44 % of the population holds private health insurance. Specialist physician fees in the private sector are unregulated; physicians can charge any price they want, subject to market forces.
> We find that patient risk factors account for a small portion of the variance in fees and out-of-pocket payments
> Physician-specific variation, responsible for much of the variation in total fees and OOP payments, could include physician characteristics that patients value, such as bedside manner, experience or reputation, or factors related to physiciansā circumstances or preferences. A key physician-level factor that may drive the variation is the perception of quality or skill differences between physicians. This perception can come from either consumers or physicians themselves about their quality or skill levels in comparison to other physicians in the physician's local market. [...] which can lead to large price variation and non-transparency of fees.
Recommendations
> The government, private health insurers and physicians themselves could all play a more active role than they currently do. The government, for example, could mandate the disclosure of price and quality information for all procedures that receive government subsidies, insurers could provide incentives for the disclosure of such information, and physicians could change their referral practice to give preferences to other physicians who are willing to be transparent about their prices and quality.
- globalnews.ca U.S. doctors perform kidney transplant on awake patient in milestone - National | Globalnews.ca
A medical team in the U.S. has performed a rare kidney transplant during which the patient was awake throughout the procedure and was discharged the next day.
- Quadriplegic manās MAID death from bedsore results in public inquiry being ordered | Globalnews.caglobalnews.ca Quadriplegic manās MAID death from bedsore results in public inquiry being ordered | Globalnews.ca
During his hospital stay, the Quebec man developed a major pressure sore on his buttocks. In late March, he received medical assistance in dying to put an end to his suffering.
- www.cnbc.com Gileadās twice-yearly shot to prevent HIV succeeds in late-stage trial
Gilead's experimental twice-yearly medicine to prevent HIV was 100% effective in a late-stage trial, the company said Thursday.
- www.theglobeandmail.com Policy that forced patients to switch to cheaper medications saved B.C. $730-million, report says
The B.C. government said Friday that the money freed up through its biosimilar switching plan allowed the province to expand public coverage of other drugs and devices
> A British Columbia provincial policy that forced people with chronic illnesses such as Crohnās disease and rheumatoid arthritis to switch to cheaper medications saved the province more than $730-million over five years, according to a new government report. > > The B.C. government said Friday that the money freed up through its biosimilar switching plan allowed the province to expand public coverage of other drugs and devices, including Trikafta, a life-changing treatment for cystic fibrosis and continuous glucose monitors for people with diabetes.
- Pentagon ran secret anti-vax campaign to undermine China during pandemic | Reuters Investigation
> At the height of the COVID-19 pandemic, the U.S. military launched a secret campaign to counter what it perceived as Chinaās growing influence in the Philippines, a nation hit especially hard by the deadly virus.
> Reuters identified at least 300 accounts on X, formerly Twitter, that matched descriptions shared by former U.S. military officials familiar with the Philippines operation. Almost all were created in the summer of 2020 and centered on the slogan #Chinaangvirus ā Tagalog for China is the virus.
> The military program started under former President Donald Trump and continued months into Joe Bidenās presidency, Reuters found ā even after alarmed social media executives warned the new administration that the Pentagon had been trafficking in COVID misinformation. The Biden White House issued an edict in spring 2021 banning the anti-vax effort, which also disparaged vaccines produced by other rivals, and the Pentagon initiated an internal review, Reuters found.
- www.theguardian.com Scientists develop glowing dye that sticks to cancer cells in breakthrough study
Experts say fluorescent dye, which spotlights tiny cancerous tissue invisible to naked eye, could reduce risk of cancer returning
- Self-surgery on South Pole
30 April 1961 Leonid Rogozov does appendectomy on himself during his Antarctica expidition with help of driver and meteorologist.
- www.theguardian.com āI could bench-press 100kg. Now, I canāt walkā: Lucyās life with long Covid
Before the pandemic, Lucy Keighley ran a gym, worked as a personal trainer and went on gruelling, exhilarating runs. But after three and a half years of illness, she isnāt sure she will ever recover
> I was incredibly strong and fit,ā says Lucy Keighley. And she looks it, in the photo she is showing me, taken a few years ago. She is with her best friend, Lorna; they have just completed a 15-mile race on the North York Moors. āIt was a brutal race,ā she says. āBut it was great. I was happy.ā Today, although itās quite dark in the room (she doesnāt get on well with bright light), I can see a tear rolling down her cheek. āI donāt know if Iām ever going to get back there.ā
> In theĀ most recent findingsĀ by the Office for National Statistics, released in April, an estimated 2 million people in England and Scotland (3.3% of the population) self-reported experiencing long Covid, meaning symptoms that continued for more than four weeks after infection, although many reported their symptoms had lasted two years or longer. OfĀ those, about 1.5 million felt their day-to-day activities were affected, while 381,000 said their day-toāday activities were ālimited a lotā. Worldwide, at leastĀ 65 million peopleĀ are estimated to have longĀ Covid.
- www.nature.com MDMA therapy for PTSD rejected by FDA panel
Scientific advisers to the US Food and Drug Administration vote overwhelmingly that the risks of MDMA treatment for post-traumatic stress disorder outweigh the benefits.
- medicalxpress.com Study shows most doctors endorsing drugs on X are paid to do so
A team of medical researchers affiliated with several institutions in the U.S. has found that a high percentage of doctors posting endorsements regarding drugs on the social media site X were paid to do so by the makers of the drugs.
- www.theguardian.com Trial results for new lung cancer drug are āoff the chartsā, say doctors
More than half of patients with advanced forms of disease who took lorlatinib were still alive after five years with no progression
- www.clinicaltrialsarena.com AAN 2024: Myostatin inhibitors on the horizon for the treatment of SMA
At the American Academy of Neurology (AAN) 2024 Annual Meeting, Biohaven presented its Phase III RESILIENT trial (NCT05337553), which investigates the efficacy and safety of taldefgrobep alfa in patients with spinal muscular atrophy (SMA).