My wrists have "barely carpel tunnel" according to the one doctor I went to see. I find not having to move the mouse all day with my wrists (as well as a split keyboard with risers) has eliminated my wrist problems at work.
In the past my wrists used to hurt, my father had carpal tunnel and I didn't want to risk it, so I switched to a keyboard centric WM and switched to a trackball. I haven't experienced wrist pain in years, although I think it might be mostly related to the keyboard centric WM since I went back to a mouse for gaming a while back and when my trackball broke I didn't bother getting a new one.
That being said trackballs are amazing for working on limited spaces or soft surfaces (e.g. a couch or bed), once I've gotten used to it I could work on the sofa just as efficiently as I would on a desk without extra monitors, but now my desk has two large monitors and plenty of space for the mouse, so it's less of an issue.
duuude its been my first demand at my last 3 jobs... best trackball available please! i like to joke with them, "youre not paying me enough to move my arm that much"
I have a Sanwa Gravi, I had to "grind" some place in the "hole" because the ball was touching it and it was annoying, but it's the best trackball, index ball, and LMD and RMD and wheel are controlled with thumb.