AbstractAims. To assess the survival benefit of aortic valve replacement (AVR) in patients with normal flow low gradient severe aortic stenosis (AS).Method
In patients with normal flow low gradient severe AS, AVR was associated with a significantly improved survival compared with those who received standard medical treatment.
This editorial refers to ‘The impact of aortic valve replacement on survival in patients with normal flow low gradient severe aortic stenosis: a propensity
Low-gradient aortic stenosis (AS) [i.e. an aortic valve area (AVA) <1 cm2 with a mean transvalvular gradient <40 mmHg and/or peak jet aortic velocity <4 m/s] is a frequent finding, with up to 40% AS patients harbouring discrepant results at transthoracic echocardiography (TTE) examination.1 This discordant grading pattern raises challenges and uncertainties regarding the true severity of the valve disease. Therefore, a thorough, integrative approach including assessment of flow status has been proposed in recent guidelines
Conclusions The nonprescription drugs loperamide and mitragynine are associated with disproportionate reports of life-threatening ventricular arrhythmia in North America.