rowinxavier @ rowinxavier @lemmy.world

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2 yr. ago

The crazy thing is we actually do have things that work in humans but not in mice. Mice are omnivores and are very different in terms of optimal energy state. They tend to run in glucose more easily than on fat and their whole biology is built to be small and fast, with short life spans.

Checking how DNA repair works in an animal which lives for maybe 2 years is great for understanding DNA repair in short lived organisms, but we have tk repair damage for 50 times as long. It is just so much more complex and requires such different tools when you switch from maybe 2 years to maybe 80 years, it really isn't sane to assume it will all carry over.

Now for an accute toxin, say tobacco, sure, some things work just fine. There is not a huge difference between humans and mice when subjected to cyanide or arsenic. Being crushed by a falling piano is going to kill both of us. But a chronic poison? That will take decades to kill? That is very different. We can shed cells in a different way to how they can. We have more mass to store things. We have more energy storage. We have bigger kidneys with more opportunities for filtering. We are different.

When we enter ketosis we have some fairly significant cancer responses. When we maintain fasting for 5+ days we have a fairly large bump in autophagy, a state where the body kills off and recycles damaged cells. This state can cause some types of cancer to be more obvious to our immune systems and allow the tumor to be attacked. In some cases otherwise inoperable tumors can be removed after shrinking them through fasting. This does not replicate in mice. So yes, some treatments (not cures because that doesn't really apply) do work in humans and not in mice.

To be clear though, the two defined states are separated by a voltage gap, so either it is on or off regardless of how on or how off. For example, if the off is 0V and the on is 5V then 4V is neither of those but will be either considered as on. So if it is above thecriticam threshold it is on and therefore represents a 1, otherwise it is a 0.

An analogue computer would be able to use all of the variable voltage range. This means that instead of having a whole bunch of gates working together to represent a number the voltage could be higher or lower. Something that takes 64 bits could be a single voltage. That would mean more processing in the same space and much less actual computation required.

I used spite.

I lived with my partner and two friends who all smoked at the time. We all decided to quit on new years day and by about 2am both of my friendship had started again and by 4am my partner had started too. Pure burning spite and superiority kept me from starting again.

It felt really good to my petty younger self to be haughty and superior, but I was definitely ungracious about it. My partner somehow managed to stay with me through that, they are a very tolerant person, and we ended up getting married and are still together now 19 years later.

My partner also quit about 10 years later using a vape. They outsourced nicotine dosage to me and I was manually mixing their juice, so I reduced it very very slowly. Each time I reduced it the frequency of puffs went up for a while then tapered back to the previous level. It took about a week to level out and about two weeks to use the bottle and I would then adjust again. It took most of a year to slowly land at zero but then it was done and vaping was only done with nicotine free juice and it only lasted a month or two after that. I would strongly encourage it as a less harmful version of smoking and as a reasonable quitting aid.

So other people will detail all of the products which can assist you but I am going to recommend some exercises instead. Much of the pain comes first from fatigue of muscles and second from the soft posture that happens after fatigue. Both cause pain, though in different ways, and both can be helped by a few fairly simple exercises.

First, standing on your toes will build your arch. Going up and down, bouncing, slowly raising and lowering, all of these will help train your calves and the support muscles in and around your feet and ankles. This will help stabilise your ankles and that will actually cascade all the way up your legs, back, and even neck. Some people I have worked with have had a reduction in neck pain from simply bounding on their toes when possible.

Second, you need flexibility in your ankles. 6 hours standing is absolute abuse for your joints and they need your support to be OK after that. Squats, especially deep squats, can help with ankle flexibility and strength. Reaching your toes will lengthen the muscles on the back side of your body, all the say up. Getting to having your hands flat on the floor while having your legs straight will improve your back flexibility a lot. Rolling your ankle a little to the side while very very lightly loaded can train the stabiliser muscles for strength at extension.

I would also recommend going barefoot when possible, at home etc, so that your feet can do the work. This will help them train for when you have to wear shoes.

As for the ibuprofen, it is a tool but it has consequences. I would recommend using ice packs and hot water bottles to alternate the temperate of your ankles when they are sore. Spend about 5 minutes with the ice, then 5 with heat, back to ice again if you need. Ibuprofen removes inflammation but you actually need inflammation to heal well, so use it as needed but try to do the temperature methods first if you can. The same goes for paracetamol, use it when it is the best tool but try the other tools first.

Oh, and for your ankles and feet just feeling awful consider a bucket of fairly hot water. Soak your feet for as long as you like. It works really well and is mostly consequence free.

I had tonnes of problems when I used Mint which went away when I switched to Arch. I switched from Arch to EndeavourOS and didn't get the problems coming back. I think EndeavourOS is about on par with Mint in terms of difficulty and set up time, but seems more stable and capable. I use KDE and the associated Bluetooth management stack and it works well.

That said, in the rare case I do have an issue I just restart Bluetooth through systemctl and it starts working again. The most recent time I had this was when I had my left earbud working on my phone and my right on my computer. It worked fine until I stepped away for a second, it dropped from my phone but not my computer, but then the left earbud tried to join up with the right connecting to the PC and everything broke. A quick restart of Bluetooth and boom, all good.

Sudden changes are generally worth investigating. Unfortunately it can be hard to get actual medical care relating to menstruation and other "women's issues" as a lot of doctors are quite limited in their training.

The key would be to get an idea of how much you atet bleeding and at what level of consistency. Is it a constant flow? Is it coming in waves after cramps? Does it come with pain beyond normal levels? Is the colour different to what you are used to? Bright red?

If you are having ongoing heavy bleeding there could be an issue and it should be investigated if possible. That said, my partner has had heavy periods since childhood and only suffers low iron as a consequence, so the range of normal or fine is fairly wide.

Fantastic, the dishwashing gloves are an absolute winner. If she finds something they aren't good enough for consider a second set of gloves inside them, such as cotton gloves or disposable latex gloves. This further reduces sensation through the gloves and enhances the protection.

Just a quick point on the cost of nuclear. A large part of the cost of nuclear is due to the very intense safety systems which have been added on a little at a time. Each small safety thing has increased the cost but nobody has taken all of the intentions of those changes and integrated them into a stable and safe system without the need for all the little safety features.

The best example I can give is cars. Adding air bags, lane change detection, car in front detection, ABS, and so on each makes cars safer, but never questions the underlying adduction that cars are good. Why not trains?

In rectors we can have passive safety systems where the moderator is a liquid which is blocked in by a solid plug. The solid plug is frozen moderator and sits at the bottom of the system. If the power is cut or fails the plug stops being cooled and melts, draining the moderator. Without the moderator the neutrons are going too fast to trigger the chain reactions and everything stops. No sensors or control systems are needed, it just passively stops and cools naturally, while also being way cheaper.

Could it also have been the texture of the insides of the pumpkin? Was she wearing thick gloves? I know a couple of people who would find that specific texture awful. That said, knowing she can step away is good, being reminded at the first sign of trouble can help, but ultimately she will have to learn her own limits and learn how to assert them. This is a great situation to learn from and practice that skill.

A great result and a lovely memory for her to keep.

If your daughter has trouble with smells maybe try an n95 mask. They reduce most odours enough to the make them more tolerable, so it can be useful to test that tool and see how much it helps.

That is essentially what gluetun does. It is a little simpler to set up given that it is all preinstalled and you just select your provider and details and it is done. And again, you just specify the network for other containers to use the gluetun service and it is done. Very simple, easy for using many services through one VPN connection, and available on things like CasaOS with simple setup.

A quick point to add. Adding fat to your meal makes it more filling and for longer. The worst fats are trans fats, second worse are polyunsaturated fats, and mono seem to be fairly good along with most saturated fats. In terms of cost some of the vegetable fats are much cheaper but they often have trans fats which are essentially toxic and they also go rancid very easily.

Saturated fats are generally solid at room temperature and don't absolutely need to be refrigerated on cool to moderate weather days. If you would sweat the butter would too, so put it in the fridge.

If you add a small amount of mince to your beans it will stretch really far and add tonnes of flavour and protein without breaking the bank. Cheaper mince comes with more fat but if you are making beans you want that, so get the cheaper mince, lean is not helpful.

Beans on rice freezes well for weeks. Beans without rice is good for months frozen. Beans with rice and any cheese or sour cream is not OK frozen. Beans with cheese microwaves well, but add sour cream after heating.

To make it more satisfying you can add a little bit of some chilli sauce. Hotter sauces go further, but the best is fermented sauces. The cheapest chilli sauces are full of sugar and water, so they just sweeten and dilute rather than flavour your dish.

If your beans tastes sour add a small amount of sugar, stir for a minute, and test again. Sugar fixes the sourness quite well.

For extra flavour a stock cube can be added. I would recommend beef stock for beans, but it will work with chicken or fish too. Most stocks are now vegan because they re synthetic, but they add a lot of flavour and are perfectly fine to eat.

The best option if you can manage it is to learn how to make a beef broth from bones. You boil the bones for hours, around 8 or so should do, and the bones will start to soften and become translucent. At this point all the nutritional goodness of the bones is in the broth. You can then use this as a base for making stew, beans, soup, etc, or you can reduce it by open top heating it and letting the steam leave. This will make a strong stock you can use to add flavour and nutrition to other meals for the cost of some energy and cheap bones.

A slow cooker can make cooking all of this much easier and safer. Electric slow cookers are able to be set up in the morning and have dinner most of the way ready by dinner time. The slow steady heat is great for bones and for softening meat and the easy of use is just fantastic.

Very interesting. So what I read from that is when you have an opt in system the doctor has to work with the patient's kin to come to a decision. The presentation of information in that situation is secondary to the moral decision of whether to do the donation and the distress of the death is going to get in the way of the conversation.

When the system is changed to opt out the default being donation means information is just that, information about what will happen. Changing what happens is still an option but information can get through better and the relationship between the doctor and kin is much more level and less involved in persuasive argument.

I think opt out is a better system for a bunch of reasons, not least of which is reducing the burden on families. If you need an organ to survive and more are available you are more likely to find a match and survive, preventing your kin from suffering that loss. The donor is dead either way, so one group of kin suffer, but preventing the second group of kin suffering a second death is very worthwhile.

This system is fundamentally broken. In Australia there is no path by which people on Centrelink would not have their payments processed for more than a few days. I remember a bank issue which caused a bunch of people to not get their payments on time and it was a major issue, people were absolutely livid. That was only a couple of days late and was resolved promptly with hardship temporary support available for those who really needed it.

For the system to be able to fail like this means those who designed the system want it to fail this way. They could change the funding mechanism to make sure SNAP is immune to government shutdowns if they wanted to. They have chosen not to so that they can use hurting poor people as a political weapon. Removing this weapon should be the goal of any reasonable party and it should be urgent. There are many similar funding holes that can be closed with reasonable legislation and would take away the impact of political dysfunction from the poorest and most vulnerable of society. Choosing to do otherwise is choosing that harm.

Based on what I read about it, the game comes with custom glove controllers. It would be a significant amount of work to substitute them with something more modern and very unlikely to actually work. I would consider it likely effectively lost.

As a fellow Aussie I share your conclusion, though the Made in Australia plan from the Albanese government seems like it could change the game. Producing solar panels here would make purchasing them cheaper even if just from the shipping costs. Add the federal investment and the creation of demand and it should get cheaper again.

Now I do worry about things going the way of the NBN, starting with a goal of future proof fibre to the home being chipped away by the LNP until it was a small upgrade on internet service funded by the government but not anything like the goal. I want good green tech, not just barely solar sometimes.

Coal is dying as an investment but existing coal plants will likely run for a long while. Overall demand for energy is rising, the new demand is being met mostly with renewables, but there is a small amount of that increase that is being met by a small increase in coal usage. As renewable manufacture gets faster and more efficient I expect the coal growth will reverse, but it is all about when. If it happens quickly we have less apocalyptic damage. If it happens slowly then we will be more fucked.

Solar is far and say the cheapest form of new energy to roll out. Wind is a not so close second. Coal is getting more expensive by the day. The only reason to roll out coal is insufficient production of solar and wind. It takes time to increase manufacturing capacity but we are getting there and we can do this.

I am reminded of hospital acquired infections being treated like car crashes or plane crashes.

Car crashes kill massive numbers of people each year, just under 5 per 100,000 people per year here in Australia. That is way down and we are quite low globally, with the EU overall around 9 and 14 for the USA. We have taken fairly agressive steps to curb road deaths and made real progress, but a certain number of deaths is accepted as necessary. A crash is investigated for fault attribution and insurance but not for preventing a repeat.

Plane crashes are totally different. If something caused a plane crash we figure it out, make a mitigation, and make it never happen again. Flying is one of the safest modes of transport and it keeps getting safer.

In hospitals most of them had the car crash mentality for hospital acquired infections. A hospital putting in a plane crash mentality investigator for their Infection Prevention chair will have very different outcomes, especially over time. Someone got an infection from bad clean technique? Make it a checklist item. Someone still got another infection? Change gloving technique so that you wear two layers and only touch the outer gloves with clean inner gloves. Another case? Have a second staff member assist with your donning of PPE and going through the checklist. Each step reduces the risk, each mitigation makes everyone safer. Eventually you have so few infections it is hard to test new processes.

For anyone wondering edgydoc.com is the site for the aforementioned doctor and he is a blast. But yeah, if you treat a consequence as a cost of doing business nothing changes. If you make failure an existential risk you can eliminate problems. Corporations are run by people. Those people should be accountable for the crimes of the company.

Done is success, you have to draw something bad to learn to draw something good, and based on how good that is you have drawn a lot of bad already, one more for your stack of lessons. Your proportionality is good, I would recommend looking at some art in a similar style you consider better and try to identify what makes it work, for example defining muscles using small lines that hint at a shape so the legs have more detail and are less blank, or making the limb portions different in length based on their relative perspective.

Traffic cone on top of the canister, bottle of water down through the top. Drowns the canister and deprives it of oxygen, ending the reaction.

That said, if you put it in a bucket of water you need to submerge it and the gas can be caustic, so wear gloves with good coverage and chemical resistance.