I feel like I am the pickiest reader I know. I prefer reading light, humorous type books. But as it turns out, writing things that are genuinely funny is a difficult ask; generally, at least to me, a lot of "funny" writing comes off as trying too hard and failing miserably.
I will also just stop reading whatever if the book has any one of several items that piss me off. This includes, but is not limited to: bad/unrealistic dialogue, unnecessary romance/sex, cliche or unrealistic plots, or unlikable characters that I am supposed to root for.
I have started so many books - ones that were recommended by trusted friends or that were on a bestsellers list - only to put them down within the first few chapters because I just couldn't stand whatever the book was doing or trying to do.
I'm actually genuinely sad I don't enjoy reading more, but I refuse to slog through books that I just don't like, so the end result is that I don't read very much. It's frustrating.
A guy I used to work with had very similar symptoms just before he was diagnosed with Celiac's Disease. You can always ask your doc to test for it. Simple blood draw.