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  • Uh, we don't really know how our drugs work (especially the older ones). We have a vague understanding of their mechanisms, but we really don't know how they work. We don't even have a clear idea of what the structures of most drugs look like, and how they interact with their binding sites.

    Luckily, we don't actually have to know how they work, to know that they work. Instead we use clinical trials and real world evidence to support their use.

    (Fun fact: there's actually a branch of drug development called phenotypic drug discovery which actually does away with the understanding of the mechanisms altogether. )

  • Pfizer says it will price Covid treatment Paxlovid at nearly $1,400 for a five-day course, which researchers estimate only costs Pfizer $13 to produce. That's a 10,000%+ markup. Shameful.
  • Pharma companies spend a majority of their time trying to make new unique drugs, they just fail most of the time. The ones that succeed tend to be ones that are similar to ones that succeeded in the last, which is why you get multiple drugs in the same class, but it's not all they do. For example, we've essentially cured some types of cystic fibrosis, and there's an effective vaccine for malaria now - all developed in the last 10 years.

    I don't want to pretend that the big pharma companies aren't evil, but they do have incentives that align with improving human health.

  • Adult Autism Reality
  • I'm so sick of seeing this particular piece of misinformation, you absolutely can immigrate to New Zealand with diagnosed Autism.

    Those restrictions essentially only apply to people who require full time carers (i.e. who need a large dollar amount of support needs, who can't pay for it themselves).

  • *Permanently Deleted*
    [meme] Trains are 100000x easier to electrify and automate than cars, so why does everyone keep talking about electric and driverless cars?
  • Public Transport takes twice as long to get anywhere for me (and I live fairly close to both trains and buses), and motorcycles are way more dangerous, and can't really carry anything except yourself. Cars are a happy medium between the two, which is why people use them.

  • InitialsDiceBearhttps://github.com/dicebear/dicebearhttps://creativecommons.org/publicdomain/zero/1.0/„Initials” (https://github.com/dicebear/dicebear) by „DiceBear”, licensed under „CC0 1.0” (https://creativecommons.org/publicdomain/zero/1.0/)SA
    Same @lemmy.world
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