Contramuffin @ Contramuffin @lemmy.world

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3 yr. ago

Basically everything is more powerful than the steam deck. The steam deck wasn't really designed to be powerful, moreso it's meant to be the "reference model" for handhelds: cheapest, weakest, yet also most mainstream. My understanding is that the Z2 should be substantially more powerful than the steam deck, and though it should also use more battery than the steam deck, it also has a larger battery capacity to make up for that increased power draw. Price, on the other hand... Well, nothing can even get close to the sort of price that a steam deck offers

Only under hotter, dryer conditions. Under wetter and cooler conditions, the inefficiency of C3 is offset by the extra steps required for C4, which makes C3 favored in those conditions

Oh, I've got such a good one. In high school, I was in Science Olympiad (basically a science club). I was always kind of a wishy-washy member, never really a serious or particularly reliable member. But one day, the club needed designs for a new shirt, and they decided to ask the members for some designs that the members would then vote on. I decided to submit a satire shirt.

I obviously can't share the full design for privacy reasons, but I went ahead and made it jingoistic/military themed. Fighter jets flying overhead, tanks rolling through. To make sure that people knew I was being totally serious about this clearly relevant shirt, I put a stick figure holding a science-looking flask in the corner of the shirt. And then to make sure that everyone knew that we were smart, I put the equation: "3+3=6." All text in comic sans, of course.

Anyways, no one got the joke. My design got 1 pity vote. I don't think anyone even believed me when I said that it was a joke, which out of everything was kind of the saddest part for me.

Do you have anything that you're passionate about? It seems unusual that you would think there's nothing to talk about. If not, I would consider finding a nice passion. I wouldn't consider video games to be a passion, unless that's something that you actively choose to do over other options

Either people have bought out the non-34B's, so that only the 34B remains; or non-34B people have gone elsewhere, which caused the store to think that every customer is 34B.

Which is it???

Frankly, it seems somewhat self-evident based on the fact that Valve chose a Hawk Point 2 CPU (last gen laptop CPU with 2 big and 4 little cores) with a last gen laptop RX7600M GPU on a desktop, and also the fact that Valve calls them "semi-custom."

But here's the analysis: https://youtu.be/sJI3qTb2ze8

Depends on how you loosely you feel about "why". Was battery life a consideration? Sure. But it wasn't really the primary consideration. Valve's current track record is that they are masters at making a product that's surprisingly workable out of scrapyard parts that they got for cheap.

Valve didn't design the Steam Deck's chip - AMD designed it for Microsoft initially before the deal fell through. Then AMD offered the chips to Valve for cheap to recoup the costs.

Likewise, Valve didn't intentionally choose the parts in the upcoming Steam Machine. Valve just bought AMD's excess stock. That's why the Steam Machine uses such an unusual and unbalanced CPU/GPU combo.

I honestly think SD2 is going to use x86, not for any particular reason, but because AMD is most likely going to have excess stock that's x86 at the time that Valve designs it

It depends on which part of your eye is nonfunctional. It turns out there's multiple redundancies for sensing light, so you could be blind but still be submitting signals to your circadian clock. If your eyes are completely nonfunctional, then yeah you'd have a pretty screwed up clock.

Young-ish introvert guy here. It's definitely getting harder and harder over time. IMO the big problem is that nowadays, people don't need to learn to communicate. And so many people never learn. There's too many interesting things to do while you lock yourself away in your house. In the past, even introverts had to learn to communicate. What else were they going to do? Sit and stare at the wall?

What's the solution? Well, you have to be more deliberate with your time and effort. You need to learn to communicate, so learn to communicate. My rule of thumb is that, on average, you need to spend at least half of your waking day outside. Whether for work, or hobby, or shopping, etc. - being outside for any reason is infinitely more useful for socializing than staying indoors.

Also, don't stagnate. It's very easy to get comfortable with what you've been doing and to keep doing what you've been doing. Again, be deliberate about how you choose to spend your time. Pick up new skills. Learn new hobbies. Try out new restaurants. Explore a bit. The more you learn, the better you get at learning. Become well-rounded, knowledgeable, cultured.

Nine sols. A metroidvania with parry-based combat and insanely good plot.

Perhaps euthanasia is cruel, but the alternative must also be considered.

My cat died from some sort of cancer. We noticed blue welts growing from her face years ago, but the vet said that they were harmless, some sort of allergic reaction. They got bigger over time, and more started to appear. Tests were done, but the vets still said that it was nothing to worry about.

Over time, her personality changed. She was never really extraverted, but she still liked attention. Over time, she started hiding from people. She only came out to eat, then went back to hide again. We never saw her walking around like she did in the past.

The night when she died, she pulled herself to visit the bedroom, then crawled back out into the living room and curled up onto the sofa and waited to die there. We knew something was wrong when we woke up the next day because she left a trail of blood that led us to her. At that point, it was already too late.

In hindsight, it was clear - she was in constant pain for years. It was why she was hiding from people, why she seemed to start avoiding attention, why she stopped doing anything that she enjoyed. That night, she knew she was going to die, and she paid everyone a final visit before resigning herself to die on the sofa. It was an undignified, likely painful and slow death, that was preceded by years of debilitating pain. If she were given the choice, would she have chosen euthanasia? I'm not sure, but it feels clear to me that she knew she was going to die and was suffering for years.

My understanding is that there was a scene where a young girl rides a naked man/woman around. Apparently it has since been changed to make the child older, but... I can perfectly understand why anyone would be hesitant to accept such a game based on that description alone. Even if it's not intended to be sexual, the developers were certainly pushing the line

I think it really depends on your definition of what counts as year of Linux. Will Linux usage ever beat Windows or Mac? Of course not. But it can definitely get popular enough that companies have to think really hard about whether they need to support Linux or not. And meanwhile, Linux isn't going to get popular overnight (or in a year, for that matter). So do you consider the year of the Linux to be the end of growth? Middle of growth? Or beginning of growth?

For me, I think year of the Linux desktop already passed in 2021, with the launch of the steam deck (where I'm defining year of Linux to be the point where Linux usage picks up and will hopefully end at a point where companies have to take Linux seriously)

7 is a soft reboot and it's really good, I think it's a good starting point. 8 continues from 7, and neither games mention anything from the first 6 games. The only returning character is Chris Redfield, and only as a side character that you see 1% of the time

Thanks, we had that issue but I think we just solved it by downclocking

Although, that would assume that companies don't already trend towards doing so

This, apparently:

And this is the second oldest:

Pro tip: don't. It'll make you feel worse than if you just isolated yourself.

The incentive structure of dating apps is completely twisted and makes you feel like every part of yourself is getting commodified and ranked.

Find some social groups or clubs and go hang out there. You'll have a much better time. Many people don't mind if you aren't comfortable with communicating, just being present is a positive in their book.

That makes sense, but unfortunately in a frustratingly unhelpful way. NF-kB is the central mediator of cellular immunity. What that means is that everything that needs an immune response triggers NF-kB and everything immunity-related gets activated due to NF-kB. Likewise, TNFa is the prototypical pro-inflammatory cytokine. It's remarkably good at triggering immune responses in a wide variety of cells, and every immune response that I know involves TNFa in some way.

In other words, having inflammatory symptoms be caused by NF-kB>TNFa is less of a "that's an interesting pathway" and more of a "yeah, of course NF-kB and TNFa would be involved, what's new?"

The concern is that we don't really know what's activating NF-kB in the first place, and so as a result you can't really fix the core problem. And because NF-kB and TNFa are involved in basically every immune process, it's hard to tell if these proteins are the ones actually responsible for causing your symptoms. You'd be operating on a hunch, essentially. Though I will say that your unusually nondescript and broad symptoms do seem roughly in line with what I would expect from TNFa signaling.

All that to say, I'm not a doctor and I have no experience with translating knowledge into practicable therapies, so definitely talk to a doctor about it. But TNFa is very easy to detect in your blood, and if TNFa is causing your symptoms, then it's really easy to just check to see if you've got high TNFa in your blood when you're taking the antibiotics vs. when you're not. If you had the money, you could even buy a test kit yourself and get an answer in a single day, assuming you know how to use the kit

I'm not familiar with COVID, but it does sound to me like you've got long COVID. I've got no advice on that front - frankly, I don't think anybody really knows what's up with that. I get the impression that that's why the advice that you've received so far are primarily focused on treating symptoms.

If your hypothesis is correct that your antibiotic is helping through its immunomodulatory effects, then it looks like it's acting primarily through inhibiting cytokine production. Messing with cytokines will certainly affect your ability to fight off infections, since that's how your body signals to immune cells that there's something wrong. Of course, immunity is all about balance, and you don't need to block cytokine signaling completely in order to decrease it to manageable levels... A brief search shows that there are inhibitors for TNFa, which based on your links seem to be what you're leaning towards as the molecular mediator.

Have you considered bringing this up to your doctor? I'm not sure how feasible it would be to do a "trial run" with one of these inhibitors to see if it helps your symptoms. However, it may be simple enough to ask for a blood test to measure the amounts of different cytokines in your blood. My understanding (don't trust me on this - I'm not a clinician) is that standard blood tests don't typically measure cytokines, which is potentially why your blood tests so far haven't been able to pick anything up out of the ordinary. That would at least help rule in/out any possible causes.

I will also point out an alternative hypothesis that might be worth considering - it could be that the antibiotic is depleting your microbiome, which would reduce the same cellular pathways that your antibiotic is said to inhibit due to your cells being in less contact with bacteria. Have you tried other antibiotics, and did they have a similar effect?