There's a guide in the readme and also a wiki entry on how to use it with p2pool
For the people who missed it:
Monero os is a live linux system that starts mining monero on boot. It is inspired by nicehashOS but is completely free and open source.
After some time of developing MoneroOS. I finally implemented the most requested feature. P2Pool! I am currently looking for beta testers to find issues and report back. You can join our public matrix room if you are interested #moneroOS:matrix.org.
You can grab the latest release from https://github.com/4rkal/MoneroOS . Read about how P2Pool works on MoneroOS here https://github.com/4rkal/MoneroOS/wiki/P2Pool
Basically title. Does running with the flags --light-mode or --no-randomx --no-cache affect profitability? Not talking about hashrate.