Scientists regenerate neurons that restore walking in mice after paralysis from spinal cord injury

phys.org Scientists regenerate neurons that restore walking in mice after paralysis from spinal cord injury

In a new study in mice, a team of researchers from UCLA, the Swiss Federal Institute of Technology, and Harvard University have uncovered a crucial component for restoring functional activity after spinal cord injury. The neuroscientists have shown that re-growing specific neurons back to their natu...

Scientists regenerate neurons that restore walking in mice after paralysis from spinal cord injury::In a new study in mice, a team of researchers from UCLA, the Swiss Federal Institute of Technology, and Harvard University have uncovered a crucial component for restoring functional activity after spinal cord injury. The neuroscientists have shown that re-growing specific neurons back to their natural target regions led to recovery, while random regrowth was not effective.

33 comments

Insurance: Nah we aren't gonna cover it. And for some reason our economical opinion trumps your own doctors medical opinion.
- This is actually one case insurance companies would be ALL OVER a real fix. People with spinal injuries have tons of medical complications that cost throughout their entire life. An insurance company would definitely be interested in unloading persistent fiscal drains like that.
  
  Don’t get me wrong, the medical insurance industry is a fucking terror, especially in the US with the degree of regulatory capture involved. In this one case though, a real cure would serve their interests at anything less than a massive cost on their part.
  
  The difference though is that this treatment would require hundreds of hours of ongoing work from medical professionals for each treatment. What they did was use single cell RNA sequencing to determine which subpopulations of cells are supposed to connect and where, before stimulating cell growth and guiding each RNA mapped subpopulation to where it's roughly supposed to go. That's one thing for anatomically complete sub-millimeter spinal cord injuries in mice, but a massive endeavor for human spinal cords.
  
  If you've seen the bioengineered cancer treatments where researchers grow immune cells to target a single individual's tumor, the amount of specialized work that goes into that pales to what current technology would require for this sort of spinal regeneration, and that's for relatively simple small scale lesions. Multiple lesions or large scale cell death could result in attempting to selectively guide millions of microscopic axons in neat clusters for over a foot.
  
  I wouldn't be surprised if insurance companies refused to pay for cell regrowth, and instead went for implants that are comparatively much simpler to install and modify in brain-computer interfaces that skip over the damage. This is a great advancement and does open the door for recovering from spinal cord damage, but this is one of those treatments that people are going to get because they need to fill FDA trials and won't charge, or because the patient is filthy rich.
- "Yeahhhhhh here's the thing, a wheelchair costs fifty dollars, while the revolutionary treatment that will give you full use back is fifty ONE dollars...
  
  So you see, there really is only one sensible option..." -every insurance company everywhere even if the prices were literal
  
  But but... If I can get back to work I can make the $1 whilst also getting back into the workforce and by extention the tax base providing a lifetime of benefit to the public and keep my family out of poverty..
  
  Denied.
What I've learned this means in practical terms is, "Wow! We are really good at healing mice!"
- Well that’s great news for all the mice who can afford the treatment.
  
  Yeah this treatment is only going to benefit the top 1% of mice in the end
This is the right way to solve paralysis, not Elon-killing-monkeys.
- Monkeys are the next step.
  
  Well, probably dogs or cats first. But eventually monkeys.
  
  "Professor: As a man enters his 18th decade, he thinks back on the mistakes he made in life. Amy: Like the heaps of the dead monkeys? Professor: Science can not move forward without heaps!"
  
  180 years old?
- if only there were elon-killing-monkeys
  
  I hope they eat well.
- This was done by Courtines‘ Team in Switzerland not Musk.
  
  Their comment was in relation to Neuralink being in the news about killing monkeys, recently, not attributing OP’s news to him.
Fuck animal testing
- Animal testing has saved the lives of millions and improved billions. It's gruesome, but necessary. Especially for research like this.
- It does make you wonder what caused spinal injury in these mice. I do not suppose there is a sufficient natural supply of these kinds of injured mice.
  
  But, if not animal testing, how do you propose to develop the treatment?
  
  It's a little grim, but there's a standard SCI (spinal cord injury) guillotine that drops a weight with an angled wedge to cause a near perfectly replicable SCI. The mouse is sedated, but it's not exactly a good time for the mouse.
  
  But yeah, the alternative is testing on humans, which, I really don't think we need a reminder on why that's super illegal.
- Are you vegan?
- People who value the lives of small rodents over the lives of fellow human beings should have their heads checked, because their moral compass is seriously out of whack.

33 comments