Lisa gets a Guinea pig, who is a bit of a terror, and burrows through the iconic sailboat painting. Homer buys a similar painting from the Van Houtens, which turns out to be worth tens of thousands of dollars. After a lot of fighting about who should get the money, it turns out the painting was a forgery all along.
That is an amazing guess, but sadly incorrect. I scrubbed that episode and while Marge does look at it similar to the shot here, there is already a hole from the Guinea pig. At the end of the episode is another shot, but it includes Homer who adds his own art.
That painting has always sparked my imagination. That's it, a novel about whaling! That's something you haven't seen before. Thank you, "Scene from Moby Dick"!