Y’all are gonna have to define “spoilers,” because to me, a “spoiler” is something that reveals a major plot point, not a random, completely missable scene that you only come across if you do one certain event that you might not do in a quest that can actually be skipped, and if the RNG gods chose a certain character to bear the brunt of it.
One of the reasons to play through multiple times is just having different Origin character party member compositions. One or more characters can chime in during dialogue, and changing the combination of characters can dramatically change the whole scene. I have all the murder hobo vibe characters, and it's like the devs knew this combo would be common and I'm getting hella scenes I never saw in 2 previous playthroughs.
The only 3 at this point in the game that, if they used the alignment system, I'm sure would be one type of evil or another. I've had a couple surprise moments where all 3 join in a short discussion, playing off each other's lines. I've had Lae'zel before, but I've never really kept Astarion around (unless I needed something with a DC of 30 lockpicked) and this is my first evil run, so Minthara isn't a smouldering pile of ash this time.
One of my main complaints so far is that other party members seldomly pipe in during convos. I get why they didn't do it more, as the game is massive with already a sheer amount of dialogue, but it makes my party feel kinda flat. Like sure they do little quips or remarks while walking around, but even those aren't very frequent. Maybe it changes further into the game, but I'm about 35 hours in and done almost everything in act 1 so far. I'll be thrilled if this changes in later acts!