I really don't think so. (Perhaps depends on how one thinks of "radically different") I think the vast majority of roleplay characters could be described as "Me if I were $X" (A pirate/Evil/noble/etc)
This is how I did things before I knew I would get euphoria from playing a woman. This is actually still how I do things, only now as a woman. My avatar has always been variations of myself.
That's called meta-roleplaying, honestly not a fan of it. It really limits and ruins the experience, both in video games and TTRPGs. The goal of fantasy is to do things you can't do, to be someone who isn't you.
It's a bad practice that I was told when learning TTRPGs that I should work on breaking it. You can get much more out of the game if you do. Like why limit yourself to a certain race or class just because you think it's what you'd be if you were in the game, that's not you in the game, it's someone else, whoever you want it to be in fact, don't squander that opportunity.
It's one thing that always puzzled me about this argument. Like in a fantasy you should be aiming to try new things, think outside of the box. I mean some people maybe don't but in my opinion if you're not then in my opinion you're playing the game wrong.
I always played and play beast races if games have them any humanoid race feels rather alien to me and among them women less alien and men sre the most alien.
Most of the games I play there are no stat differences between genders - Minecraft is unique among them in having two shapes to choose from with different hitboxes, but Minecraft has no gender except what the players bring in
So no bonus or penalty for choosing one way or other
BG3 though, as a game with a dress up component, took so long to get a dress, everyone seems to wear trousers and shirt