Create is overwhelming me with its complexity and power.
I like combining several smaller mods to achieve things. Like an autocrafting table from mod X and transporting pipes from mod Y. Energy generators from X, crushers/furnaces/etc. from Y, and so on.
I built a fully functional, self-sustaining Krusty Krab this way.
I use what I have at hand and what I like to play with. Create is too complex for me, as I mentioned. So I go with things like Indrev, Tom's Storage, sometimes Powah, and so on. There's a neat pipe mod, I think it's from Fluid Dynamics. The Auto crafter was its own mod. Depends on the modpacks.