I agree that LEO was probably a strong influence, just like Moebius and Alien. I also think they really found their own style with the ecosystem they created, by how they mixed different influences and then added their own twist.
This series started as an [adultswim] short called Scavengers. "Reign" was added afterward to make it distinct from what was effectively the pilot, which had a more minimalist approach but featured the same themes that were featured throughout the series.
Loved both. Definitely recommend the Scavengers pilot AFTER the main series Scavengers Reign though.