I've had LMDE6 installed since it's release day and everything has been fine. For the past week it's been dropping my wifi card randomly. It is not recognized by rfkill nor lspci after it happens. Only reboot helps.
Does anyone know why it might happen? Kernel is 6.1.0-21-amd64 but I don't know has the kernel been updated recently.
Which brand is it? I have an HP and have a similar problem, adding "pcie_aspm.policy=performance" to the kernel parameters mostly mitigates it but on Fedora like distros it may still have errors I don't know how to fix.
I had some hard to track down intermittent network issues when I upgraded from LMDE5 to LMDE6 - the solution was to get a newer kernel from backports - its fairly painless...
I'd start with checking logs with journalctl as a privileged user. If the device disappears, there should be logs about it. Maybe that will point the way.