It certainly changes the tone

The Culah Out Uf Spayce

Guillermo del Toro's Cabinet of Curiosities has an episode with an Eldritch horror theme called Pickman's Model. Crispin Glover does a super heavy Boston accent and it is fantastic.

Gonna be playing a character straight from Lovecraft lore in a ttrpg my friend is developing. Totally gotta give her an accent