I can’t speak to all systems or configurations, but my desktop is Arch-based with the Nvidia 535 driver (a few versions old, I’m still waiting for the explicit sync driver support), I run the game through Xwayland (no gamescope), and I’ve been using protonge 9-2 as the compat tool. The game runs really smooth in my experience, and on protonge 9-2 I don’t have issues switching windows/workspaces.
I do run the game in exclusive fullscreen— I recall the window having a single white pixel border in borderless fullscreen.