What organizations/causes/people/whatever are most worthwhile to donate to?

If you're in the U.S., the Institute for Justice does a ton of good work. They're a nonprofit that picks up cases to help out those who can't afford to do so. They've gotten a lot of cases all the way to the supreme court.

They're committed to challenging things like qualified immunity, or civil asset forfeiture. Things that really need to be taken on given what we see happening today.

Edit: Link: https://ij.org/cases/supreme-court-cases/