There are times where after inputting an action it takes a while to register. Mostly with summons especially magic hand.
Load times are fine, fast travel load times are typically pretty good within the same act region at least.
It's crashed fully once in 25+ hrs. But there have been a few bugs where I couldn't interact with something or I couldn't select a menu choice (like examine). Most of the time these are fixed by restarting the console.