I have not finished this colony, but am burned out after a previous long playthrough. I may start a similar colony in a few months when I have the itch to play again.
The colonists are a genotype with debuffs in all skills apart from melee and social, + have the slow study gene. They are great at melee, robust and have strong melee damage, as well as being 50% larger than an average pawn. The slaves do nearly all the actual work. Death by downed is at 50% so we take lots of prisoners and slaves are the main export and basis of our economy. I planned to give all prisoners the beautiful gene to make them more profitable, but had not quite got that far.