An angel of God expelling Adam and Eve from the Garden of Eden, but with Trump as the angel; Biden and Kamala as Adam and Eve; and the White House as the Garden of Eden.
It's meant to show Adam and Eve being cast out of the garden of Eden. Trump is depicted as an angel holding a flaming sword, which is a reference to this Bible verse:
He drove out the man, and at the east of the garden of Eden he placed the cherubim and a flaming sword that turned every way to guard the way to the tree of life.
Genesis 3:24 NIV
The artist is trying to imply that the Biden administration's choices will cause them to be expelled from the White House (the "garden"), and that Trump (an "angel") will be instated by God to prevent them from ever returning.