Some great adventure hooks for an Appalachian Horror Game - American Horror is not limited to Lovecraft
Systems you might use
Lotfp
Modern Hack
Ghost Hack
Vampyre Hack
Magus Hack
Agents of O.D.D.
Esoteric Enterprises
Tall Tales
Blood and Bullets
Owl Hoot Trail - such a hoot :)
Under Western Skies
GURPS Lite