The real issues? Social anxiety, general guilt and regret about the past, the acceptance and occasional pain in knowing that I'll never have a partner.
But the situation has been the same for about a decade and I've moved past the point where it bothers me other than acute episodes. I'm fortunate enough to have a good job and enough money that I don't have to worry about housing or food, and aside from work I can basically do whatever I want (the positive side of "no partner"). I have hobbies and am going to start traveling soon and work keeps me busy, so I don't really have grounds to complain.
Also, at some point if you're not dangerously depressed, it just becomes a part of life and the new baseline. I feel "meh" at the best of times aside from when I level up on OSRS, and having that kind of pessimistic outlook does have some advantages. I don't really panic when something goes wrong because everything is shit anyways, so the boiler breaking down or w/e is just another Tuesday. Makes life much more chill then the rollercoaster of being an optimist.