The comic was called “Loss” because it was about the comic character losing his unborn child. It became a meme because it didn’t fit the tone of the comic series (normally about gaming and non serious stuff).
So now when anyone mentions the word “loss” (as OP did in the title of this post), people meme about it in some way. Usually by posting a minimalist version of the comic.
It's a meme or maybe comic that's referenced like one.
Loss is a 4 panel comic of (1) guy going to a hospital, (2) asking someone at desk for directions, (3) talking to doctor about their loved one, and (4) mourning over said love one lying in bed.