In Fallout 2 there's an option to become a slaver, which lets you make some extra money in the short term, but comes with a hefty reputation penalty with almost everyone in the wasteland for the rest of the game, since it comes with a "SLAVER" tatto on your forehead. You'll be locked out of some quests, some characters refuse to join you and bounty hunters will be harassing you. It's 100% not worth it, though it can make for a more challenging playthrough.