Don't take your medication
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Is this supposed to be punching up or punching down?
Neither, idk. You feel like it's made in poor taste?
Yes.
It's not poor taste that's the problem, it is ableist nonsense, but more importantly - dangerous. Delete it. (or don't of course, but then you don't get to pretend to give a shit about the people you're punching down at)
Nerd
Not necessarily, depending on the audience. Sometimes jokes land and sometimes they don’t, I wouldn’t stress about it too much
This is a meme on the internet Karen