On my first play through the first thing that went wrong was Tammy dying, After that I did not at all focused on agriculture, I also didn't go out on expeditions so I didn't gather any food. So when the famine hit Sol's mother died. After a while Sol's father died from the infection/spores. The colonies defenses where also pretty bad :/ The colony did manage to survive in the end but it wasn't that great overall.
Yeah there are some events, that make it a bit more complicated, and there even is a way to prevent it, but its hsrd to miss.