You can use virustotal for any game/file under 650MBs; This meme was created as a joke, good security practices should always be followed.
No anti virus will be 100% accurate, viruses get missed all the time, while legitimate software can acquire false flags.
I would never recommend just running a random .exe you find on the internet with wine as any non-root protected files could potentially be damaged; With Bottles (the application) all files outside of the created bottle are not visible to programs ran/installed inside the bottle.
If you really want to try something, throwing caution to the wind, running it in a wine BOTTLE that's created just for that program, has a low chance of damaging your computer. (This does not mean "safe")
The pursuit of knowledge is endless; It's good to ask questions, but always do your own research too, as myself or anyone else could not know what they're talking about.