I've really embraced the main bus for my playthrough and thus far it's done wonders for keeping everything neat and orderly. My only complaint is that it's stating to get annoyingly chunky and splitting off the bottom lanes burns though like half a stack of yellow underground belts, but at this point that's the more of a problem for the construction bots.
I also use a Main bus, but realised quickly that for science its currently not a viable option. I have 12 lanes of iron and copper and for just 90spm I need 6 lanes of copper. I will instead use my blueprint for science, paste it around and supply everything with trains.
The main bis will end up being only used for my mall.