I have homozygous C677T mutations in my MTHFR gene, with homozygous COMT mutations further limiting neurotransmitter regulation. I feel very different when consuming foods high in activated folates, or related vitamins/supplements.
I have the same mutations. In me they caused severe depression for almost 20 years. Started megadosing l-methylfolate, and I wanted to live again practically overnight. So yeah, it can def make you feel different.