The notable exception is Qubes, but the isolation issues which X11 typically has are avoided by virtualization. This isolation only applies to apps running in different qubes (virtual machines), apps running in the same qube are not protected from each other.
Supports full-disk encryption during installation.
Doesn't freeze regular releases for more than 1 year.
We recommend against "Long Term Support" or "stable" distro releases for desktop usage.
Also, not that it matters much, but it has a strong stance towards open-source software, not allowing closed software in its repositories. Although closed software can be installed by using RPMFusion