AI generated comics usually have the off-white background and thick lines, like in this comic. But reverse image search finds this from 2018, so it's unlikely AI generated.
Interesting. If you'll notice, the comic you linked isn't the same as this one. This appears to be a pointless AI copy of the original:
The off-white background, the thick lines, AND the guy staring at the viewer rather than where he'd actually be looking, as he is in the original, are all AI indicators.
Funny. I was thinking the ai post leaned towards Don Hertzfeldt's style, then saw the "original" and it look even more like Hertzfeldt (see hands), which means ai even manages to fuck up stick-figure fingers!
There are so many AI comics posted here I've come to recognize their tells pretty well. It's like an uncanny valley sort of feeling. It kind of surprises me that it's still so bad at making simple drawings look like a person did them.