A month with LFS (Linux From Scrath) + musl + eudev + libressl + qi package builder helper. What a great experience.

For musl, I've been actively using it for 7 months now and just encounter minor issue. Some packages need to be patched for musl compatibility (I borrow the patches from alpine linux).

I use Chimera Linux which is musl based. Compatibility is great. If you have the source, you are probably fine.

It can be a pain for projects that ship binaries as part of the build. Two examples that I have run into:

• The Ladybird browser uses vpkg and the version their scripts download assumes Glibc. You can build vpkg itself on musl but the whole process is a pain.
• dotnet requires a binary build of dotnet to bootstrap from. There are musl builds available but they assume GCC and Chimera uses Clang. Not really a musl problem now that I think of it.

Anyway, I use a Distrobox of Arch on Chimera. If I do run into something (like the two above), I just pop into that and problem solved.

Flatpak is essentially the same solution as they run in a container and the freedesktop base is Glibc based.

Not only is musl not generally a problem but, these days, it is trivial to work around it.