I've never actually played the original but have had a huge amount of fun with many "Powered by the Apocalypse" games, especially Monster of the Week, my group were all huge x files fans so it was a great fit.
I've never played Slugblaster but all the rest were great fun. However, I have had the very best sessions with Apocalypse World 2 and Monsterhearts 2. If you are into either of those genres and have the group for it you're in luck. A good session feels better than literally taking happy drugs.
(Finding the right group for Monsterhearts is quite the trick though.)
Lkke Kleenex and Xeroxes for tissues and photocopies, DnD is now the generic term for tabletop analog RPGs. All the wizards of the coastal AND land-locked regions can suck on that fact.