Y'all is the opposite of offensive for trans people. I lived in the south for a while, and I now use y'all specifically to be inclusive. I wouldn't say "you guys" is offensive to trans women, but I would say for me and likely other trans women it briefly brings to mind being misgendered in the past, so I would call it a small kindness to ube as gender neutral as possible.
I feel like I have watched in real time as Y'all has gained usage up in the Canadian Queer community.
I am old enough to still regard "hon" as demi hostile but "dude" seems to be drifting more and more gender neutral. At heart we may all just be ninja turtles all the way down